Systemic sclerosis & Raynaud's
Gastrointestinal dysmotility is associated with proton pump inhibitor refractory oesophagitis in patients with systemic sclerosis
Authors' conclusion
Our findings suggest that gastric and small intestinal motor dysfunction may be an important contributor to the development of PPI-refractory oesophagitis in patients with systemic sclerosis.
Study context
- Population
- Patients with SSc who underwent oesophagogastroduodenoscopy while on proton-pump inhibitors (PPI) treatment, single-centre cohort
- Participants
- 69 patients
- Exposure
- PPI-refractory erosive oesophagitis vs endoscopically normal oesophageal mucosa
- PPI-refractory oesophagitisn = 23
- Normal mucosan = 46reference
- Outcome
- Factors associated with PPI-refractory oesophagitis
Methodological detailssingle-centre cohort, multivariate regression adjusted for diffuse subset
- Single-centre cohort
- Multivariate regression adjusted for diffuse subset
Main finding
As reported in the abstract
GI dysmotility (abnormal gastric emptying and/or small bowel dilated loops)
PPI-refractory oesophagitis
66
%
Normal mucosa
8%
P = <0.001
- GI dysmotility independently associated with PPI-refractory oesophagitis (multivariate, adjusted for diffuse subset): β
- 0.751, P = 0.010
Observational data: associations, not effects.
Further findings
Diffuse SSc subset · univariate analysis
P = 0.041
Absent oesophageal contractility · univariate analysis
P = 0.292
Hypotensive lower oesophageal sphincter · univariate analysis
P = 0.980
- Absent oesophageal contractility — Not independently associated (multivariate): β
- 0.044, P = 0.886
- Hypotensive lower oesophageal sphincter — Not independently associated (multivariate): β
- −0.131, P = 0.663
Original publication
Gastrointestinal dysmotility is associated with proton pump inhibitor refractory oesophagitis in patients with systemic sclerosis. Rheumatology (Oxford). Published 9 September 2024. doi:10.
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