Systemic sclerosis & Raynaud's
Distinct clinical trajectories of gastrointestinal progression among patients with systemic sclerosis
Authors' conclusion
Clinically distinct GI phenotypes exist among patients with SSc. These phenotypes are not only distinguished by GI and extra-intestinal SSc clinical complications, but they are also temporally distinct. Distinct autoantibody profiles are associated strongly with more severe GI disease.
Study context
- Population
- Systemic sclerosis (SSc) patients in a well-established cohort with at least two Medsger gastrointestinal (GI) scores≥2 Medsger GI scores
- Participants
- 2,696 patients
- Exposure
- GI severity trajectory phenotypes
- Stablen = 2,325
- Early Progressiven = 142
- Late Progressiven = 115
- Early Severe GIn = 114
- Outcome
- GI phenotypes and their trajectories of modified Medsger GI severity score over time
Methodological detailsgrowth mixture models, adjusted for disease duration
- Growth mixture models
- Adjusted for disease duration
Main finding
As reported in the abstract
GI severity trajectory phenotypes (modified Medsger GI score)
Stable
1
average score
Early Progressive
1
initial average score
Late Progressive
1
initial average score
- Four unique phenotypes identified
- 4
Observational data: associations, not effects.
Original publication
Distinct clinical trajectories of gastrointestinal progression among patients with systemic sclerosis. Rheumatology (Oxford). Published 30 August 2024. doi:10.
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