Systemic sclerosis & Raynaud's
The association of outdoor temperature and self-reported Raynaud's phenomenon severity among people with systemic sclerosis: a Scleroderma Patient-centered Intervention Network Cohort study
Authors' conclusion
Raynaud's phenomenon severity is worst at very cold temperatures but also increases with very warm temperatures, presumably due to air conditioning.
Study context
- Population
- People with RP secondary to SSc in the Scleroderma Patient-centered Intervention Network Cohort; mean age 54.8 (SD 12.7) years20,233 assessments
- Participants
- 2,243 people
- Outcome
- Past-week RP severity (NRS 0-10) across the spectrum of mean daily outdoor temperature in the week before assessment
Methodological detailslongitudinal assessments at 3-month intervals, linear mixed models with basis splines, People with lived experience of SSc contributed to study design and interpretation
- Longitudinal assessments at 3-month intervals
- Linear mixed models with basis splines
- People with lived experience of SSc contributed to study design and interpretation
Main finding
As reported in the abstract
Predicted RP severity score (0-10) by outdoor temperature
- Maximum predicted severity, at −25°C
- 6.8 points (95% CI 5.6-8.1)
- Decrease from −15°C to 5°C, per 5°C difference
- 0.05-0.21 points
- Decrease between 5°C and 25°C, per 5°C difference
- 0.37-0.54 points
- Minimum predicted severity, at 25°C
- 2.6 points [95% CI 2.5-2.7]
- Predicted severity at 35°C
- 3.5 points (3.0-4.1)
- Predicted severity at 40°C
- 5.6 points (4.5-6.8)
Observational data: associations, not effects.
Further findings
RP severity by feels like temperature (incorporating wind chill and humidity)
- Results similar to those for mean daily temperature
Original publication
The association of outdoor temperature and self-reported Raynaud's phenomenon severity among people with systemic sclerosis: a Scleroderma Patient-centered Intervention Network Cohort study. Lancet Rheumatol. Published 28 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →