Systemic sclerosis & Raynaud's
Survival and early outcomes following lung transplantation for interstitial lung disease associated with non-scleroderma connective tissue disease: a national cohort study
Authors' conclusion
Compared to IPF, patients with ILD-NSCTD have a significantly higher risk of post-operative stroke and extended hospital stays, potentially due to complications inherent to ILD-NSCTD. However, the underlying causes of these outcomes remain unclear. Despite these differences, short-term and long-term survival rates are comparable between the two groups, with consistent findings across various ILD-NSCTD subgroups.
Study context
- Population
- Patients with idiopathic pulmonary fibrosis (IPF) or ILD-NSCTD in the United Network for Organ Sharing (UNOS) database who underwent lung transplantation, May 5, 2005 to December 31, 2022
- Participants
- 610 vs 11,610
- Exposure
- ILD-NSCTD vs IPF in lung transplant recipients
- ILD-NSCTDn = 610
- IPFn = 11,610reference
- Outcome
- Overall survival (Kaplan-Meier)
Methodological detailspropensity-score matched, national registry (UNOS)
- Propensity-score matched
- National registry (UNOS)
Main finding
As reported in the abstract
Overall survival after propensity matching
- Overall survival rates remained similar between the groups
- ILD-NSCTD vs IPF: log-rank, p=0.953
- Propensity matched
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Post-operative LOS | P < 0.001 |
Post-operative LOS
- Longer post-operative hospital stays with ILD-NSCTD
Subgroup analyses
- Subgroup analyses yielded consistent results
Cause of death
- Infection was the leading cause of death
Safety
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| Post-operative stroke | 1.75 (1.12–2.74) | P = 0.015 | |
| 0.20.5125Adjusted odds ratio (log scale) |
Original publication
Survival and early outcomes following lung transplantation for interstitial lung disease associated with non-scleroderma connective tissue disease: a national cohort study. Clin Exp Rheumatol. Published 29 August 2024. doi:10.
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