Systemic sclerosis & Raynaud's
Predicting trajectories of lung function decline in systemic sclerosis–related interstitial lung disease
Main finding · Mortality, most progressive vs stable/slow FVC trajectoryResult — go to the resultHazard ratio 2.95 95% CI 1.74–4.98Authors' conclusion
Distinct FVC trajectories are associated with different survival outcomes and the most important predictor of a progressive FVC trajectory was existing ILD severity.
Study context
- Population
- SSc patients with ILD and ≤7-year disease duration
- Participants
- 444 patients
- Exposure
- Most progressive forced vital capacity (FVC) trajectory vs stable/slow FVC trajectories
- Outcome
- FVC decline trajectories and their association with mortality
Methodological detailsmulticentre, latent class trajectory analysis, logistic regression with backwards selection
- Multicentre
- Latent class trajectory analysis
- Logistic regression with backwards selection
Main finding
As reported in the abstract
Mortality, most progressive vs stable/slow FVC trajectory
Hazard ratio
2.95
95% CI 1.74–4.98
Most progressive trajectoryvs Stable/slow FVC trajectory
HR 2.95 (95% CI 1.74–4.98)
Observational data: associations, not effects.
Further findings
Baseline predictors of progressive trajectory
- Baseline FVC associated with progressive trajectory
- P < 0.001
- CRP elevation associated with progressive trajectory
- P = 0.039
Baseline FVC ≤72% predicting progressive trajectory
- Sensitivity
- 0.88
- Specificity
- 0.91
Factors associated with lower baseline FVC
- Older age, Caucasian race, longer disease duration, anti-topoisomerase I presence and elevated CRP
- Exploratory analyses
Original publication
Predicting trajectories of lung function decline in systemic sclerosis–related interstitial lung disease. Rheumatology (Oxford). Published 3 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →