Systemic sclerosis & Raynaud's
Cardiovascular and venous thromboembolic events in systemic sclerosis: epidemiological analysis of the Clinical Practice Research Datalink
Main finding · CAD, PAD, peripheral venous thromboses and PE during follow-upResult — go to the resultAdjusted hazard ratio 1.84-3.01Authors' conclusion
We have identified an increased risk of cardiovascular events and VTE, both prior to a diagnosis of SSc and within 8 years of SSc diagnosis.
Study context
- Population
- Systemic sclerosis (SSc) patients and matched non-SSc comparators in the Clinical Practice Research Datalink (83.7% female)mean follow-up 8 years
- Participants
- 877 vs 5,262
- Exposure
- SSc vs matched non-SSc comparators
- SScn = 877
- Non-SScn = 5,262reference
- Outcome
- CAD, cerebrovascular disease, PAD and VTE
Methodological detailsmatched 1:6 by age, sex and location, Cox regression adjusted for traditional cardiovascular risk factors, validated case-ascertainment strategy, prevalent and incident SSc analysed separately
- Matched 1:6 by age, sex and location
- Cox regression adjusted for traditional cardiovascular risk factors
- Validated case-ascertainment strategy
- Prevalent and incident SSc analysed separately
Main finding
As reported in the abstract
CAD, PAD, peripheral venous thromboses and PE during follow-up
Adjusted hazard ratio
1.84-3.01
Observational data: associations, not effects.
Further findings
Baseline prevalence of coronary arterial disease (CAD), peripheral artery disease (PAD) and venous thromboembolism (VTE) (pre-dating diagnosis)
- Higher background prevalence in the SSc cohort
Original publication
Cardiovascular and venous thromboembolic events in systemic sclerosis: epidemiological analysis of the Clinical Practice Research Datalink. Rheumatology (Oxford). Published 30 May 2025. doi:10.
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