Systemic sclerosis & Raynaud's
Systemic sclerosis and cancer in the UK: an epidemiological analysis using the clinical practice research datalink
Authors' conclusion
We have identified an increased risk of cancer diagnosis following, but not before, SSc diagnosis.
Study context
- Population
- Systemic sclerosis (SSc) patients identified in the UK Clinical Practice Research Datalink (10.1 million individuals)
- Participants
- 1,588 SSc cases
- Exposure
- SSc vs matched non-SSc comparators
- Outcome
- Cancer occurrence following SSc diagnosis
Methodological detailsmatched 1:6 on age, sex and GP practice, Cox regression, nested case-control study (matched 1:6)
- Matched 1:6 on age, sex and GP practice
- Cox regression
- Nested case-control study (matched 1:6)
Main finding
As reported in the abstract
Cancer after SSc diagnosis
Each group vs Non-SScAdjusted hazard ratio (95% CI)
Prevalent SSc
1.41(1.14–1.75)
Incident SSc
1.32(1.04–1.67)
Observational data: associations, not effects.
Further findings
| Outcome | Prevalent SSc | Incident SSc | Non-SSc | P value |
|---|---|---|---|---|
| Proportion developing cancer, incident cohortIncident SSc vs Non-SSc | — not stated in the abstract | 11.2% | 9.7% | P = 0.02 |
| Proportion developing cancer, prevalent cohortPrevalent SSc vs Non-SSc | 14.8% | — not stated in the abstract | 12.1% | P = 0.03 |
| Lung cancer, prevalent cohortPrevalent SSc vs Non-SSc | 2.6% | — not stated in the abstract | 0.9% | P < 0.001 |
| Overall cancer incidence | — not stated in the abstract | — not stated in the abstract | 13.9 /1000 person years | |
| Cancers after SSc diagnosis (number)Commonest cancers: mucocutaneous, lung, breast | 116 events | 90 events | — not stated in the abstract |
— not stated in the abstract
- Cancers after SSc diagnosis (number) — Total cancers following SSc diagnosis
- 206
- Cancers after SSc diagnosis (number) — Mucocutaneous cancer
- 4.5%
- Cancers after SSc diagnosis (number) — Lung cancer
- 2.1%
- Cancers after SSc diagnosis (number) — Breast cancer
- 1.9%
- Overall cancer incidence: SSc (prevalent and incident) 17.6 /1000 person years
Cancer prior to SSc diagnosis (case-control study)
- No increased risk of cancer prior to SSc diagnosis
Original publication
Systemic sclerosis and cancer in the UK: an epidemiological analysis using the clinical practice research datalink. Rheumatology (Oxford). Published 13 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →