Systemic sclerosis & Raynaud's
Lung cancer risk in systemic sclerosis: data from an inception cohort and meta-analysis of published studies
Authors' conclusion
Long-term follow-up data from an SSc inception cohort indicate a fivefold increased lung cancer risk in SSc, nearly doubled among female patients.
Study context
- Population
- Patients evaluated within 12 months of systemic sclerosis (SSc) onset, January 1995–December 2020, followed until December 20242,110 person-years follow-up
- Participants
- 180 patients
- Outcome
- Age-standardised incidence ratio (SIR) of lung cancer
Methodological detailssingle academic inception cohort, age-standardised incidence ratio vs Global Cancer Observatory database, Cox proportional hazards models, meta-analysis of lung cancer SIRs
- Single academic inception cohort
- Age-standardised incidence ratio vs Global Cancer Observatory database
- Cox proportional hazards models
- Meta-analysis of lung cancer SIRs
Pooled result
As reported in the abstract
Lung cancer age-SIR
- Lung cancer diagnosed, n
- 12
- Mean time from SSc onset to lung cancer (years)
- 10.2±5.9
- Age-SIR, entire cohort
- 5.1 (95% CI 4.7-5.4)
- Age-SIR, male
- 3.8 (95% CI 3.5-4.1)
- Age-SIR, female
- 9.5 (95% CI 8.7-10.3)
Further pooled results
Lung cancer determinants (Cox models)
- Diffuse subtype, HR
- 4.22 (95% CI 1.03-17.35)
- Smoking history, HR
- 4.49 (95% CI 1.14-17.69)
- Digital ulcers (inverse association), HR
- 0.13 (95% CI 0.03-0.63)
Meta-analysis: pooled lung cancer age-SIR (17 studies, 27,563 SSc patients)
- Pooled age-SIR
- 3.85 (95% CI 2.63-5.63)
Original publication
Lung cancer risk in systemic sclerosis: data from an inception cohort and meta-analysis of published studies. Clin Exp Rheumatol. Published 31 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →