Systemic sclerosis & Raynaud's
Hand function impairment in Systemic Sclerosis: determinants through investigations of clinical, radiographic and ultrasonographic features
Authors' conclusion
Skin fibrosis and US-detected tenosynovitis were the most significant variables explaining hand disability as measured by CHFS.
Study context
- Population
- Real-world cohort of Systemic Sclerosis (SSc) patients, 3 centresconsecutive patients, 3 centres
- Participants
- 140 participants
- Outcome
- Determinants of hand function impairment measured by Cochin Hand Function Scale (CHFS)
Methodological detailsmulticentre, external validation cohort, univariate and multivariate analyses
- Multicentre
- External validation cohort
- Univariate and multivariate analyses
Main finding
As reported in the abstract
Correlates of CHFS scores
- Cochin Hand Function Scale (CHFS) correlated with modified Rodnan Skin Score (mRSS) (univariate and multivariate)
- p<0.001
- CHFS correlated with ultrasonographic (US)-detected tenosynovitis (univariate and multivariate)
- p<0.01
- US-detected tenosynovitis with sclerosing pattern, univariate
- p=0.01
- Calcinosis, univariate
- p=0.02
- US-detected tenosynovitis with sclerosing pattern, multivariate (not significant)
- p=0.06
- Calcinosis, multivariate (not significant)
- p=0.055
Observational data: associations, not effects.
Original publication
Hand function impairment in Systemic Sclerosis: determinants through investigations of clinical, radiographic and ultrasonographic features. Semin Arthritis Rheum. Published 22 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →