Systemic sclerosis & Raynaud's
Clinical trajectories of hand function impairment in systemic sclerosis: an unmet clinical need across disease subsets
Authors' conclusion
Hand function deteriorates over time in more than 50% of SSc patients despite available therapies.
Study context
- Population
- Patients with systemic sclerosis (SSc) (limited and diffuse cutaneous subsets) from 10 centres; median (IQR) disease duration 5 (2–11) years201 analysed
- Participants
- 396 patients
- Outcome
- Hand function deterioration (Cochin Hand Function Scale; MCID and patient acceptable symptom state)
- Follow-up
- 24 months
Methodological detailslongitudinal, multicentre, observational, consecutive enrolment
- Longitudinal
- Multicentre
- Observational
- Consecutive enrolment
Main finding
As reported in the abstract
Clinically significant worsening of hand function
Patients reporting clinically significant worsening
105
52.2%
Patients reporting unacceptable hand function, baseline to 2 years
27.8% to 35.8%
p<0.001
Observational data: associations, not effects.
Further findings
Factors associated with worsening hand involvement (LASSO analysis)
- Male gender, disease subset, Raynaud's Condition Score, tenosynovitis and pain among key factors
Original publication
Clinical trajectories of hand function impairment in systemic sclerosis: an unmet clinical need across disease subsets. RMD Open. Published 12 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →