Systemic sclerosis & Raynaud's
Cross-validation and sensitivity to change of EULAR ScleroID as a measure of function and impact of disease in patients with systemic sclerosis
Authors' conclusion
ScleroID demonstrates strong correlation with validated clinical measures and responsiveness to changes in standard of care, supporting its use in both clinical practice and trials. ScleroID captures the multidimensional burden of SSc regardless of disease subsets.
Study context
- Population
- Patients with systemic sclerosis (SSc) and ScleroID questionnaires from the observational cohort STRIKE
- Participants
- 271 patients
- Exposure
- ScleroID across very early, limited and diffuse cutaneous SSc subsets
- VeSScn = 69
- lcSScn = 139
- dcSScn = 63
- Outcome
- ScleroID score
Methodological detailsobservational cohort (STRIKE), 12-month follow-up
- Observational cohort (STRIKE)
- 12-month follow-up
Main finding
As reported in the abstract
VeSSc
2.1
median · IQR 3.6
lcSSc
3.4
median · IQR 4.4
dcSSc
4.7
median · IQR 4
P < 0.001
Observational data: associations, not effects.
Further findings
ScleroID by disease activity
- Patients with high disease activity had significantly higher ScleroID scores than low ones
- P = 0.003
ScleroID domains by digital ulcers, pulmonary disease or SIBO
- Higher scores in their relative domains
- P < 0.005 for all
Correlation with other patient-reported outcomes (PROs)
- High correlations of ScleroID and its domains with all other PROs
- P < 0.05
Sensitivity to change · 12 months
- Changes in ScleroID strongly correlated with changes in clinical measures and other PROs; thresholds identified for minimal clinically important difference (MCID) changes in HAQ-DI, UCLA SCTC GIT 2.0 and Cochin Hand Function Scale
Original publication
Cross-validation and sensitivity to change of EULAR ScleroID as a measure of function and impact of disease in patients with systemic sclerosis. RMD Open. Published 10 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →