Systemic sclerosis & Raynaud's
Neutrophil gelatinase-associated lipocalin levels are associated with skin thickness and metabolic syndrome features in patients with systemic sclerosis
Authors' conclusion
NGAL serum levels in patients with SSc correlate positively and independently with extension of the skin involvement. NGAL levels also correlate with features of metabolic syndrome, such as a dyslipidaemic pattern and reduced insulin sensitivity, which may be associated with an increased risk of atherosclerosis and cardiovascular disease in patients with SSc.
Study context
- Population
- Individuals with systemic sclerosis (SSc) and healthy age- and sex-matched controls
- Participants
- 81 vs 76
- Exposure
- SSc vs healthy age- and sex-matched controls
- SScn = 81
- Healthy controlsn = 76reference
- Outcome
- Serum NGAL levels in SSc vs controls, and relationship with SSc disease features
Methodological detailsage- and sex-matched controls, multivariable linear regression
- Age- and sex-matched controls
- Multivariable linear regression
Main finding
As reported in the abstract
P = 0.67
Observational data: associations, not effects.
Further findings
Association of disease features with neutrophil gelatinase-associated lipocalin (NGAL) in SSc (multivariable)
- Extension of skin involvement, beta coefficient 5 ng/ml (95% CI 0.5-10), p=0.030
- 5
- Disease duration, beta coefficient 6 ng/ml (95% CI 0.1-12), p=0.045
- 6
- Associated with higher NGAL levels
NGAL and lipid profile in SSc
- NGAL independently and significantly related to higher LDL:HDL cholesterol ratio, apolipoprotein B:A1 ratio and atherogenic index
NGAL and insulin sensitivity (HOMA2-S%)
- Significant negative association
Original publication
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