Systemic sclerosis & Raynaud's
Fibroblast activities are associated with prolonged QTc and pulmonary arterial hypertension in patients with systemic sclerosis
Authors' conclusion
Patients with SSc and prolonged QTc, presence of PAH and high NYHA class presented an altered tissue turnover, particularly associated with increased fibroblast activation.
Study context
- Population
- Well-characterised patients with SSc
- Participants
- 102 patients
- Exposure
- SSc patients with vs without electrocardiographic (ECG) alterations, PAH and by NYHA class
- Outcome
- Association of serum ECM turnover biomarkers with subclinical heart involvement determined by ECG alterations
Methodological detailsserum biomarker panel measured by competitive ELISAs
- Serum biomarker panel measured by competitive ELISAs
Main finding
As reported in the abstract
ECM biomarkers in patients with prolonged QTc (>450ms)
- PRO-C3 significantly increased in prolonged QTc
- p=0.043
- PRO-C6 significantly increased in prolonged QTc
- p=0.027
Observational data: associations, not effects.
Further findings
Extracellular matrix (ECM) biomarkers in patients with PAH
- PRO-C3 significantly increased in PAH
- P = 0.041
- PRO-C6 significantly increased in PAH
- P = 0.019
ECM biomarkers by NYHA class
- PRO-C3 increased with NYHA class
- P = 0.024
- PRO-C6 increased with NYHA class
- P = 0.045
- C6M significantly increased with NYHA class
- P = 0.021
Original publication
Fibroblast activities are associated with prolonged QTc and pulmonary arterial hypertension in patients with systemic sclerosis. Clin Exp Rheumatol. Published 8 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →