Systemic sclerosis & Raynaud's
ERG Regulates Lymphatic Vessel Specification Genes and Its Deficiency Impairs Wound Healing‐Associated Lymphangiogenesis
Authors' conclusion
ERG and FLI-1 are essential regulators of blood and lymphatic vessel regeneration.
Study context
- Population
- Skin biopsy samples from patients with systemic sclerosis (SSc) and healthy controls; human dermal lymphatic endothelial cells (LECs); ERG and FLI-1 knockout mice
- Comparison
- SSc vs healthy controls; ERG or FLI-1 deficiency
Methodological detailsimmunofluorescence of skin biopsies, microarray transcriptional analysis, Matrigel tubulogenesis assay, endothelial- and lymphatic-specific knockout mice
- Immunofluorescence of skin biopsies
- Microarray transcriptional analysis
- Matrigel tubulogenesis assay
- Endothelial- and lymphatic-specific knockout mice
Main finding
As reported in the abstract
- ERG and FLI-1 protein levels reduced in blood and lymphatic vasculature in SSc skin biopsies
- ERG regulates lymphatic vessel specification genes (VEGFR3/FLT-4, LYVE-1, SOX-18, PROX-1); FLI-1 enhances ERG function
- ERG-FLT-4 pathway regulated in vitro tubulogenesis in human LECs
- ERG or FLI-1 deficiency similarly impaired blood vessel function in mice
- Only ERG deficiency affected lymphatic vessel regeneration during wound healing
Original publication
ERG Regulates Lymphatic Vessel Specification Genes and Its Deficiency Impairs Wound Healing‐Associated Lymphangiogenesis. Arthritis Rheumatol. Published 7 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →