Systemic sclerosis & Raynaud's
Ultrasound for day-to-day clinical use: construction of a simple discriminator between healthy skin and thickened systemic sclerosis skin
Authors' conclusion
A simple HFUS discriminator between skin thickness of HC versus SSc, i.e., DT as measured at F2L, at a cut-off of 1.5 mm, is proposed for daily use in rheumatology clinics.
Study context
- Population
- Consecutive systemic sclerosis (SSc) patients (2013 ACR/EULAR criteria) and healthy controls undergoing high frequency ultrasonography (HFUS) (18MHz probe) of dermal thickness at the left index finger
- Participants
- 63 vs 48
- Exposure
- Dermal thickness by HFUS at left index finger: SSc vs healthy controls
- SScn = 63
- Healthy control (HC)n = 48reference
- Outcome
- DT cut-off value at the left index finger (F2L) distinguishing HC from SSc skin, selected by ROC curve analysis
Methodological detailspilot study, consecutive patients, ROC curve analysis
- Pilot study
- Consecutive patients
- ROC curve analysis
Main finding
As reported in the abstract
Mean DT at F2L
- Proposed dermal thickness (DT) cut-off (HFUS discriminator between HC and SSc)
- 1.5 mm
- Specificity at cut-off
- 1
- Sensitivity at cut-off
- 0.32
- AUC of final model
- 0.83 (95% CI 0.75-0.90)
Observational data: associations, not effects.
Original publication
Ultrasound for day-to-day clinical use: construction of a simple discriminator between healthy skin and thickened systemic sclerosis skin. Clin Exp Rheumatol. Published 12 July 2024. doi:10.
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