Systemic sclerosis & Raynaud's
Self-reported skin severity and quality of life in systemic sclerosis: multicentre validation of PASTUL
Authors' conclusion
PASTUL is a feasible outcome tool that adds to assessments such as SSPRO. Skin thickening is correlated with HRQoL, particularly in early disease.
Study context
- Population
- Participants with SSc at four UK centres (mean age 56.4 years, 80.6% female; 110 lcSSc, 81 dcSSc)
- Participants
- 196 participants4 UK centres
- Comparison
- PASTUL self-assessment vs upper limb modified Rodnan Skin Score (mRSS)
- Outcome
- Construct validity: agreement of PASTUL scores with mRSS
Methodological detailsmulticentre, 12-month follow-up, Follow-up 12 months
- Multicentre
- 12-month follow-up
- Follow-up 12 months
Performance
As reported in the abstract
Correlation of PASTUL with upper limb mRSS (ICC) · baseline, 6 and 12 months
Intraclass correlation coefficients (ICC) at baseline
0.67
ICC at 6 months
0.78
ICC at 12 months
0.62
Further findings
| Outcome | Correlation | P value |
|---|---|---|
| Correlation of PASTUL with upper limb mRSS by subsetdcSSc vs lcSSc · stronger correlation in dcSSc | 0.69 vs 0.51 | P < 0.001 |
- Time to complete PASTUL self-assessment
- 5.0 · mean · SD 3.7 · min
Test-retest reliability of PASTUL
- ICC
- 0.83
- P < 0.001
Correlation of PASTUL with health-related quality of life (HRQoL) in early disease (<4 years) (subgroup)
- R
- 0.53
- Correlations weaker in the whole group
- P < 0.001
Original publication
Self-reported skin severity and quality of life in systemic sclerosis: multicentre validation of PASTUL. Rheumatology (Oxford). Published 14 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →