Systemic sclerosis & Raynaud's
Increased prevalence of osteopenia and osteoporosis in systemic sclerosis patients, including in men and young women—a case–control study
Authors' conclusion
SSc patients, including men and younger women, have lower BMD than the background population. Finger ulcers and diffuse skin involvement, in addition to older age, lower BMI and being post-menopausal, are associated with lower BMD in women.
Study context
- Population
- SSc patients (mean age 61.3 years in women, 62.2 in men) and matched background-population controls
- Participants
- 211 vs 505
- Comparison
- SSc patients vs age- and sex-matched controls from the same geographic area
- SScn = 211
- Controlsn = 505reference
- Outcome
- BMD and T-score at total hip and lumbar spine (DXA); osteopenia (T-score −1.0 to −2.5) and osteoporosis (T-score ≤−2.5) prevalence
Methodological detailsage- and sex-matched controls
- Age- and sex-matched controls
Main finding
As reported in the abstract
BMD in women, SSc vs controls
ΔT-score, total hip
−0.56
P < 0.001
SSc
ΔT-score, spine
−0.35
P = 0.011
SSc
Further findings
Osteopenia and osteoporosis prevalence in women with SSc
- Osteopenia present
- 51.6%
- Osteoporosis
- 16.5%
- vs controls
- P = 0.001
Hip bone mineral density (BMD) in women below age 45 years with SSc vs controls
- ΔT-score
- −0.93
- P
- P = 0.005
Associates of lower hip BMD in women
- Finger ulcers
- P = 0.009
- Diffuse skin involvement
- P = 0.027
- Expected risk factors (older age, lower BMI, menopause) also associated
BMD in men with SSc
- More than half displayed osteopenia or osteoporosis; numerically lower hip BMD than age-matched counterparts
Original publication
Increased prevalence of osteopenia and osteoporosis in systemic sclerosis patients, including in men and young women—a case–control study. Rheumatology (Oxford). Published 10 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →