Systemic sclerosis & Raynaud's
Comparison of Three Physician Global Assessment Instruments in Systemic Sclerosis
Authors' conclusion
PhyGAs of overall health, activity, and damage are each associated with different SSc features, and changes in different PhyGA scores are discordant 50% of the time.
Study context
- Population
- Participants of the Australian Scleroderma Cohort Study (Systemic Sclerosis (SSc))
- Participants
- 1,965 Australian Scleroderma Cohort Study (ASCS) participants
- Exposure
- Three PhyGA instruments: overall health vs activity vs damage
- Outcome
- Comparability (correlation and concordance of change between study visits) of three PhyGA instruments
Methodological detailsordered logistic regression
- Ordered logistic regression
Main finding
As reported in the abstract
Comparability of PhyGA instruments
Concordant changes of PhyGA scores between study visits
50%
Observational data: associations, not effects.
Further findings
Patient-reported breathlessness associated with PhyGA scores
- Overall health: OR 1.67, P < 0.01
- Activity: OR 1.44, P < 0.01
- Damage: OR 1.32, P < 0.01
- Only feature associated with all three PhyGA scores
Associations with changes in activity scores
- Patient-reported worsening skin disease: OR 1.25, P = 0.03
- Fecal incontinence: OR 1.23, P = 0.01
Associations with damage scores
- PAH: OR 1.25, P = 0.03
- Chronic obstructive pulmonary disease: OR 1.37, P = 0.04
- Skin scores: OR 1.02, P < 0.01
- Fecal incontinence: OR 1.21, P = 0.02
Original publication
Comparison of Three Physician Global Assessment Instruments in Systemic Sclerosis. Arthritis Care Res (Hoboken). Published 9 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →