Systemic sclerosis & Raynaud's
Increased incidence of sudden cardiac death in systemic sclerosis: data from a nationwide cohort study
Authors' conclusion
SCD occurred in 1.9% of a large SSc cohort, with an incidence rate of 300/100,000PY, representing a significant increased frequency compared to the general population.
Study context
- Population
- Individuals with systemic sclerosis (SSc) meeting ACR/EULAR criteria from the Australian Scleroderma Cohort Study
- Participants
- 1,708 individuals10,650 person-years
- Exposure
- Presumed sudden cardiac death (SCD) vs overall cohort
- SCDn = 32
- Outcome
- Incidence of sudden cardiac death (SCD)
Methodological detailsnationwide, multivariable Cox proportional hazard modelling
- Nationwide
- Multivariable Cox proportional hazard modelling
Main finding
As reported in the abstract
SCD incidence
SCD events
32
1.9%
Incidence rate
300/100,000 person-years
Observational data: associations, not effects.
Further findings
History of CAD
P < 0.001
Reduced LVEF
P = 0.004
Elevated NT-proBNP
P = 0.042
SSc heart involvement
P = 0.074
Factors associated with SCD (multivariable Cox model)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Older age | 1.15 (1.10–1.20) | P < 0.001 | |
| CAD | 2.28 (1.04–5.00) | P = 0.040 | |
| Reduced LVEF | 2.89 (1.06–7.90) | P = 0.038 | |
| Smoking history | 2.80 (1.21–6.49) | P = 0.016 | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Increased incidence of sudden cardiac death in systemic sclerosis: data from a nationwide cohort study. Semin Arthritis Rheum. Published 8 March 2026. doi:10.
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