Systemic sclerosis & Raynaud's
Frequency and implications of malnutrition in systemic sclerosis
Authors' conclusion
Malnutrition is common in SSc and confers poorer survival, HRQoL and physical function.
Study context
- Population
- Australian Scleroderma Cohort Study participants meeting ACR/EULAR criteria for systemic sclerosis (SSc) with ≥1 concurrent weight and height measurement
- Participants
- 1,903 participants
- Exposure
- Malnutrition vs no malnutrition
- Outcome
- Frequency of malnutrition by GLIM criteria
Methodological detailsmultivariable logistic regression, Cox proportional hazard models
- Multivariable logistic regression
- Cox proportional hazard models
Main finding
As reported in the abstract
Malnutrition by GLIM criteria
Diagnosed with malnutrition
43%
Severe malnutrition, of those malnourished
33%
Observational data: associations, not effects.
Further findings
Determinants of malnutrition (multivariable logistic regression)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Multimorbidity | 1.6 (1.2–2.0) | P < 0.01 | |
| PAH | 2.1 (1.4–2.0) | P < 0.01 | |
| Upper GI symptoms | 1.6 (1.3–2.0) | P < 0.01 | |
| 0.512Odds ratio (log scale) |
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Survival (worse with malnutrition)Adjusted for age, sex and dcSSc | 1.4 (1.1–1.7) | P < 0.01 | |
| 0.512Hazard ratio (log scale) |
Health-related quality-of-life (HRQoL) and physical function
- Poorer in malnourished participants
Original publication
Frequency and implications of malnutrition in systemic sclerosis. Rheumatology (Oxford). Published 28 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →