Systemic sclerosis & Raynaud's
Demographics and clinical features associated with abnormal small bowel motility in systemic sclerosis
Authors' conclusion
These findings suggest that patients with abnormal small bowel transit in SSc are more likely to be male, have more severe cardiac involvement, higher mortality and fewer sicca symptoms.
Study context
- Population
- Systemic sclerosis (SSc) patients with gastrointestinal symptoms, prospectively enrolled
- Participants
- 130 patients
- Exposure
- SSc patients with vs without abnormal small bowel transit by whole gut transit (WGT)
- Abnormal small bowel transitn = 22
- Outcome
- Clinical features associated with abnormal small bowel transit
Methodological detailsprospective enrolment, univariate and multivariable logistic regression
- Prospective enrolment
- Univariate and multivariable logistic regression
Main finding
As reported in the abstract
Features associated with abnormal small bowel transit
Abnormal small bowel transit vs Normal small bowel transitEstimate (95% CI)P value
Univariate
OR (male sex) 3.70(1.07–12.50)
P = 0.038Univariate
OR (more severe cardiac involvement) 3.98(1.10–14.38)
P = 0.035Univariate
OR (sicca symptoms) 0.30(0.10–0.94)
P = 0.039Multivariable
OR (sicca symptoms) 0.28(0.08–0.96)
P = 0.043Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality | 4.57 (1.58–13.24) | P = 0.005 | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Demographics and clinical features associated with abnormal small bowel motility in systemic sclerosis. Rheumatology (Oxford). Published 7 October 2024. doi:10.
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