Systemic sclerosis & Raynaud's
Assessment of muscle mass using chest computed tomography-based quantitative and qualitative measurements in patients with systemic sclerosis: A retrospective study with cross-sectional and longitudinal analyses
Authors' conclusion
The SMA index at L1 level on chest CT was demonstrated to be an accurate measure that is useful for detecting myopenia in patients with SSc. BMI and male sex predicted low SMA and BMI was associated with low ASMI on DXA.
Study context
- Population
- Patients with systemic sclerosis (SSc) consecutively included in the outpatient clinic of a tertiary university hospital, 2012–2021DXA subgroup of 31
- Exposure
- Chest computed tomography (CT) indices at L1 vs ASMI by DXA
- ASMIn = 31reference
- Outcome
- Associations of myopenia and/or myosteatosis with clinical features of SSc and subsequent adverse outcomes
Methodological detailsconsecutive inclusion, single tertiary university hospital outpatient clinic
- Consecutive inclusion
- Single tertiary university hospital outpatient clinic
Main finding
As reported in the abstract
Prevalence of myopenia and/or myosteatosis
- Myopenia and/or myosteatosis (any index)
- 75.7 %
Observational data: associations, not effects.
Further findings
| Outcome | SMA | SMI | SMRA |
|---|---|---|---|
| Diagnostic accuracy vs ASMI (gold standard), DXA subgroup | |||
| Sensitivity | 60% | 40% | 60% |
| Specificity | 96.2% | 96.2% | 34.6% |
| PPV | 75% | 66.7% | 15% |
| NPV | 92.6% | 89.3% | 81.8% |
| Pearson's r | 0.73 | 0.74 | 0.10 |
| Kappa | 0.611, p < 0.001 | 0.431, p = 0.012 | — not stated in the abstract |
— not stated in the abstract
Overweight/obesity (BMI ≥25 kg/m²): only skeletal muscle radiation attenuation (SMRA) reduced
- Patients with overweight/obesity with only SMRA reduced
- 73%
Factors associated with myopenia by skeletal muscle area (SMA) (multivariate)
- BMI
- P < 0.001
- Female sex
- P < 0.001
- After adjustments in a multivariate model
Factors associated with low muscle mass by ASMI (multivariate)
- BMI
- P = 0.010
- After adjustments in a multivariate model
Original publication
Assessment of muscle mass using chest computed tomography-based quantitative and qualitative measurements in patients with systemic sclerosis: A retrospective study with cross-sectional and longitudinal analyses. Semin Arthritis Rheum. Published 19 January 2023. doi:10.
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