Systemic sclerosis & Raynaud's
Association between steatotic liver disease and risk of incident SSc: a nationwide cohort study
Authors' conclusion
SLD was linked to an increased risk of incident SSc.
Study context
- Population
- Individuals who participated in a Korean national health screening program in 2012; mean follow-up 9.21 ± 1.05 years
- Participants
- 4,413,719 individuals
- Exposure
- Steatotic liver disease (SLD) categories vs no SLD
- No SLDn = 2,827,907reference
- MASLDn = 1,344,494
- MetALDn = 165,475
- ALDn = 75,843
- Outcome
- Incident SSc
Methodological detailslongitudinal, population-based, nationwide (Korean nationwide database), multivariable Cox proportional hazard models
- Longitudinal
- Population-based
- Nationwide (Korean nationwide database)
- Multivariable Cox proportional hazard models
Main finding
As reported in the abstract
Adjusted hazard ratio
1.612
CI 1.276–2.038
MASLD · statistically significant
Adjusted hazard ratio
1.575
CI 0.816–3.040
MetALD
Adjusted hazard ratio
3.063
CI 1.635–5.739
ALD · statistically significant
Observational data: associations, not effects.
Original publication
Association between steatotic liver disease and risk of incident SSc: a nationwide cohort study. Rheumatology (Oxford). Published 24 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →