Systemic sclerosis & Raynaud's
Does body composition matter in patients with systemic sclerosis?
Main finding · Predictors of mortality (linear model)Result — go to the resultOdds-risk ratio 3.345 95% CI 0.396–28.295Authors' conclusion
Patients with SSc are affected by myosteatosis and pre-sarcopenia and body composition seems to influence the overall outcome.
Study context
- Population
- Adults with SSc at a tertiary centre who underwent HRCT to assess pulmonary involvement; body composition measured at the 12th dorsal vertebra77 females
- Participants
- 87 adults
- Exposure
- Myosteatosis vs no myosteatosis
- Myosteatosisn = 63
- Outcome
- Mortality (predictors: body composition, demographics, pulmonary function tests)
Methodological detailssingle-centre, tertiary centre, stepwise linear regression
- Single-centre
- Tertiary centre
- Stepwise linear regression
Main finding
Predictors of mortality (linear model)
Odds-risk ratio
3.345
95% CI 0.396–28.295
Myosteatosisvs No myosteatosis
odds-risk ratio 3.345 (95% CI 0.396–28.295)
As reported in the abstract
- Lower DLCO predicted mortality
- P = 0.047
- Higher BMI predicted mortality
- P = 0.013
- Higher density of subcutaneous fat predicted mortality
- P = 0.005
- Lower skeletal muscle index predicted mortality
- P < 0.001
Observational data: associations, not effects.
Further findings
- Prevalence of myosteatosis (Hu <30)
- 72% · 63
Original publication
Does body composition matter in patients with systemic sclerosis? Rheumatology (Oxford). Published 23 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →