Systemic sclerosis & Raynaud's
Validation of a semi-quantitative method to assess interstitial lung disease severity and progression in systemic sclerosis by standard and low-dose high-resolution CT (HRCT) scans
Authors' conclusion
This study confirms that semi-quantitative fibrosis assessment of HRCT for SSc-ILD meets most validation criteria, supporting its use in clinical practice and showing additive value of structural to functional ILD assessment.
Study context
- Population
- SSc patients from Oslo and Zurich with HRCT images, pulmonary function tests (forced vital capacity (FVC), DLCO) and 6-minute walk test with O2 desaturation
- Participants
- 65 vs 90
- Comparison
- Zurich vs Oslo
- Zurichn = 65
- Oslon = 90
- Outcome
- Validity of semi-quantitative HRCT fibrosis extent method: content and construct validity, discrimination, sensitivity to change, feasibility, inter- and intra-rater variability
Methodological detailsmulticentre (Oslo and Zurich), standard and low-dose HRCT
- Multicentre (Oslo and Zurich)
- Standard and low-dose HRCT
Performance
As reported in the abstract
Correlation of HRCT fibrosis extent with lung function
Correlation with FVC (r)
−0.517
p<0.001
Correlation with DLCO (r)
−0.400
p<0.001
Correlation with O2 desaturation (r)
−0.500
p<0.001
Further findings
Discrimination and sensitivity to change
- Moderate correlation with DLCO (r)
- −0.377, p=0.003
- No correlation with FVC or O2 desaturation
Inter- and intra-rater reliability
- Inter-rater κ
- 0.891
- Intra-rater κ
- 0.996
- Excellent reliability
Feasibility: HRCT quantification time
- Average time (min)
- 9-15
- High feasibility
Original publication
Validation of a semi-quantitative method to assess interstitial lung disease severity and progression in systemic sclerosis by standard and low-dose HRCT scans. RMD Open. Published 27 February 2025. doi:10.
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