Systemic sclerosis & Raynaud's
Endothelial Biomarkers of Systemic Sclerosis–Associated Pulmonary Hypertension
Authors' conclusion
PTX-3 is a promising biomarker of PH risk status in patients with SSc as well as a possible marker of precapillary PH
Study context
- Population
- Patients with systemic sclerosis (SSc) (with pulmonary hypertension (PH), at high or low risk for PH) and healthy controls
- Participants
- 18 / 74 / 44 / 10
- Exposure
- Endothelial biomarkers (ADMA, sEng, PTX-3) across healthy controls, SSc-PH, SSc at high risk for PH and SSc at low risk for PH
- Healthy controlsn = 18
- SSc-PHn = 74
- High risk for PHn = 44
- Low risk for PHn = 10
- Outcome
- Serum ADMA, sEng and PTX-3 to determine SSc-PH risk or differentiate SSc-PH subgroups
Methodological detailsbiomarker comparison, ELISA
- Biomarker comparison
- ELISA
Main finding
As reported in the abstract
PTX-3
Low risk for PH
27.0
median · IQR 19.0–47.3 · pg/ml
P < 0.003
- AUC to differentiate low risk from high risk for PH
- 0.87 (95% CI 0.76-0.98, P = 0.0002)
Observational data: associations, not effects.
Further findings
PTX-3 by SSc-PH clinical classification group — Left-heart disease vs PAH or ILD · significantly lower
P < 0.01
Original publication
Endothelial Biomarkers of Systemic Sclerosis–Associated Pulmonary Hypertension. Arthritis Care Res (Hoboken). Published 15 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →