Systemic sclerosis & Raynaud's
The risk of major adverse cardiovascular events in patients with systemic sclerosis: a nationwide, population-based cohort study
Main finding · MACEResult — go to the resultAdjusted hazard ratio 1.04 95% CI 0.77–1.42Authors' conclusion
The risk of MACEs was not significantly increased in Taiwanese patients with SSc, and our investigation effectively identified the factors independently associated with MACEs in SSc patients.
Study context
- Population
- Patients with systemic sclerosis (SSc) and matched non-SSc individuals, Taiwan's National Health Insurance Research DatabasePropensity score matching (PSM) 1:2
- Participants
- 1,379 vs 2,758
- Exposure
- SSc vs matched non-SSc individuals
- SScn = 1,379
- Non-SScn = 2,758reference
- Outcome
- MACE
Methodological detailsnationwide, population-based, propensity score matched (1:2), multivariable Cox regression with time-dependent covariates
- Nationwide
- Population-based
- Propensity score matched (1:2)
- Multivariable Cox regression with time-dependent covariates
Main finding
As reported in the abstract
Adjusted hazard ratio
1.04
95% CI 0.77–1.42
SScvs Non-SSc
aHR 1.04 (95% CI 0.77–1.42)
Observational data: associations, not effects.
Further findings
| Outcome | IRR (95% CI) | |
|---|---|---|
| MI | 1.76 (1.08–2.86) | |
| Peripheral arterial occlusion disease | 3.67 (2.84–4.74) | |
| Ischaemic stroke | 0.89 (0.61–1.29) | |
| 0.20.5125Incidence rate ratio (log scale) |
Factors independently associated with MACE in SSc
- Age, aHR
- 1.02
- Male gender, aHR
- 2.01
- Living in a suburban area, aHR
- 2.09
- Living in a rural area, aHR
- 3.00
- Valvular heart disease, aHR
- 4.26
- RA, aHR
- 2.14
- Use of clopidogrel, aHR
- 26.65
- Use of aspirin, aHR
- 5.31
Original publication
The risk of major adverse cardiovascular events in patients with systemic sclerosis: a nationwide, population-based cohort study. Rheumatology (Oxford). Published 11 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →