Systemic sclerosis & Raynaud's
Risk of major cardiovascular events in patients with systemic sclerosis: insights into an underestimated concern from a systematic literature review and meta-analysis
Pooled result · MACEResult — go to the resultPooled hazard ratio 1.8 95% CI 1.4–2.3Authors' conclusion
Patients with SSc face a significantly increased risk of major CV events, including stroke and myocardial infarction.
Study context
- Population
- Cohort and prospective studies published up to November 2024 reporting hazard ratios (HRs) for systemic sclerosis (SSc) and cardiovascular (CV) outcomes
- Participants
- 12,235 participants11 studies
- Comparison
- SSc vs no SSc
- SScn = 12,235
- Outcome
- MACE
Methodological detailsrandom-effects meta-analysis, I² heterogeneity, Egger's test for publication bias
- Random-effects meta-analysis
- I² heterogeneity
- Egger's test for publication bias
Pooled result
As reported in the abstract
Pooled hazard ratio
1.8
95% CI 1.4–2.3
SScvs Non-SSc
pooled HR 1.8 (95% CI 1.4–2.3)
Further pooled results
| Outcome | Pooled HR (95% CI) | |
|---|---|---|
| nfSDecrease in heterogeneity | 1.5 (1.2–1.9) | |
| nfMIDecrease in heterogeneity | 2.5 (1.9–3.5) | |
| 0.20.5125Pooled hazard ratio (log scale) |
MACE, sensitivity analysis after removal of overlapping datasets
- Significantly elevated risk confirmed, pooled HR
- 1.9 (95% CI 1.3-2.7)
- Persistent heterogeneity (I²=88.72%)
MACE, subgroup analyses by geography
- Significant geographic variation
Original publication
Risk of major cardiovascular events in patients with systemic sclerosis: insights into an underestimated concern from a systematic literature review and meta-analysis. Clin Exp Rheumatol. Published 27 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →