Systemic sclerosis & Raynaud's
Peripheral Blood Gene Expression Profiling and Prognostic Significance for the Course of Interstitial Lung Disease in Patients With Systemic Sclerosis
Authors' conclusion
Among patients with SSc-ILD in the SENSCIS trial, PBC modules involved in myeloid lineage were associated with a faster decline in FVC regardless of MMF treatment. Higher baseline lymphoid, protein synthesis, and mitochondrial module scores were associated with a better course of SSc-ILD among patients receiving MMF treatment.
Study context
- Population
- Patients with SSc-ILD with first non-Raynaud symptom within 7 years, placebo arm of the SENSCIS trial
- Participants
- 120 vs 118
- Comparison
- Mycophenolate mofetil (MMF) vs no MMF, baseline peripheral blood cell (PBC) transcript modules and forced vital capacity (FVC) course
- MMFn = 120
- No MMFn = 118
- Primary endpoint
- Prognostic significance of baseline composite modular scores for decline in FVC% predicted
- Follow-up
- Week 52
Methodological detailsplacebo arm only, global RNA sequencing, modular analysis using 62 curated whole blood modules, mixed models for repeated measures
- Placebo arm only
- Global RNA sequencing
- Modular analysis using 62 curated whole blood modules
- Mixed models for repeated measures
Primary result
As reported in the abstract
Baseline PBC modules and course of FVC% predicted
- MMF: higher baseline lymphoid lineage and mitochondrial/protein synthesis modules associated with a better course of FVC% predicted
- MMF: higher baseline myeloid lineage and inflammation modules associated with a faster decline in FVC% predicted
- No MMF: only myeloid lineage and inflammation modules associated with a faster decline in FVC% predicted
Original publication
Peripheral Blood Gene Expression Profiling and Prognostic Significance for the Course of Interstitial Lung Disease in Patients With Systemic Sclerosis. Arthritis Rheumatol. Published 29 July 2025. doi:10.
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