Systemic sclerosis & Raynaud's
Single‐Cell Profiling Reveals Divergent Mechanisms of Fibrosis in Localized Scleroderma and Systemic Sclerosis
Authors' conclusion
These findings suggest that LoS fibrosis is driven by TLS-mediated local immune activation, whereas the systemic activation of CREB3L1-expressing fibroblasts plays an important role in SSc fibrosis.
Study context
- Population
- Skin biopsies from healthy controls and patients with localized scleroderma (LoS) or systemic sclerosis (SSc)
- Comparison
- Localized scleroderma vs SSc vs healthy controls
- Healthy controlsn = threereference
- LoSn = three
- SScn = three
- Outcome
- Prevalence of tertiary lymphoid structures (TLS) in lesions
Methodological detailsimmunofluorescence, single-cell RNA sequencing, in vitro assays, murine models
- Immunofluorescence
- Single-cell RNA sequencing
- In vitro assays
- Murine models
Main finding
As reported in the abstract
P = 0.0013
Original publication
Single‐Cell Profiling Reveals Divergent Mechanisms of Fibrosis in Localized Scleroderma and Systemic Sclerosis. Arthritis Rheumatol. Published 5 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →