Systemic sclerosis & Raynaud's
KL6 and IL-18 levels are negatively correlated with respiratory function tests and interstitial lung disease (ILD) extent assessed on high-resolution computed tomography (HRCT) in patients with systemic sclerosis-related interstitial lung disease (SSc-ILD)
Authors' conclusion
Serum KL-6 levels and IL-18 were increased in patients with SSc-ILD and showed a positive correlation with ILD severity as measured using a semiquantitative CT grading scale and negative correlation with PFT parameters.
Study context
- Population
- Patients with systemic sclerosis (SSc) fulfilling the 2013 ACR/EULAR criteria; mean age at diagnosis 57.5±15 years, 27% male
- Participants
- 74 patients
- Exposure
- SSc-ILD vs SSc without ILD
- SSc-ILDn = 28
- Outcome
- Serum KL-6, IL-18 and IL-18BP as biomarkers of SSc-ILD severity on HRCT and pulmonary function tests (PFT) (%FVC, %DLCO)
Main finding
As reported in the abstract
- Elevated serum KL-6 in SSc-ILD vs without ILD, preserved after adjusting for age and sex
- p=0.003
- Elevated serum IL-18 in SSc-ILD vs without ILD, preserved after adjusting for age and sex
- p=0.04
- Negative correlation KL-6 and %FVC
- β=−0.25, p 0.037
- Negative correlation KL-6 and %DLCO
- β=−0.28, p 0.02
- Negative correlation IL-18 and %FVC
- β=−0.38, p 0.001
- Negative correlation IL-18 and %DLCO
- β=−0.27, p 0.03
- KL-6 differentiated HRCT ILD extent grades 1 and 2
- p = 0.028
- IL-18 differentiated HRCT ILD extent grades 1 and 2
- p = 0.022
- HRCT semiquantitative ILD grade proportional to KL-6
- p = 0.01
- HRCT semiquantitative ILD grade proportional to IL-18
- p = 0.03
- Positive correlation extensive lung disease and KL-6
- β=0.42, p = 0.007
Observational data: associations, not effects.
Original publication
KL6 and IL-18 levels are negatively correlated with respiratory function tests and ILD extent assessed on HRCT in patients with systemic sclerosis-related interstitial lung disease (SSc-ILD). Semin Arthritis Rheum. Published 13 January 2024. doi:10.
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