Systemic sclerosis & Raynaud's
Semi-quantitatively scored apical extent of disease predicts change in total lung capacity in patients with systemic sclerosis and early interstitial lung disease.
Authors' conclusion
In patients with systemic sclerosis and lung involvement, disease extent and reticulation at the mid-upper zones predicted change in TLC which may be of clinical importance.
Study context
- Population
- SSc patients from a targeted healthcare program with pulmonary function tests (PFTs) and visually scored concomitant chest HRCT and PFTs at one-year follow-up (85% female, mean age at first symptoms 40 years)
- Participants
- 185 patients
- Outcome
- Change in PFT parameters (TLC, FVC, DLCO) predicted by HRCT variables
- Follow-up
- One year
Methodological detailssemi-quantitative visual HRCT scoring at five levels, regression analysis
- Semi-quantitative visual HRCT scoring at five levels
- Regression analysis
Main finding
As reported in the abstract
Prediction of change in TLC by HRCT variables
Disease extent at level 1 (apices) predicted change in TLC, adjusted R2
0.024
p 0.021
Excluding patients with emphysema or pulmonary hypertension: reticulation at level 3 predicted change in TLC, adjusted R2
0.026
p 0.020
Observational data: associations, not effects.
Further findings
Cross-sectional correlation of HRCT variables with TLC
- Disease extent and reticulation at level 1, reticulation at level 2, disease extent and reticulation at level 3 correlated with TLC, r
- 0.151-0.17 (p < 0.05)
- All HRCT variables correlated with PFT parameters cross-sectionally
Original publication
Semi-quantitatively scored apical extent of disease predicts change in total lung capacity in patients with systemic sclerosis and early interstitial lung disease. Semin Arthritis Rheum. Published 31 January 2025. doi:10.
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