Systemic sclerosis & Raynaud's
Assessment of interstitial lung disease in systemic sclerosis using oscillometric methods: a novel approach to respiratory assessment
Authors' conclusion
Our findings indicate that impulse oscillometry, particularly Fres, may provide a non-invasive and effort-independent approach to assessing interstitial lung disease in SSc.
Study context
- Population
- SSc patients assessed for interstitial lung disease (ILD) with spirometry, DLCO, impulse oscillometry (IOS) and high-resolution CT (HRCT)ILD in 62.1%
- Participants
- 66 patients
- Comparison
- IOS vs conventional spirometry and DLCO, against HRCT
- Extensive ILDn = 26
- Limited ILDn = 15
- Outcome
- Detection of presence and severity of ILD by IOS parameters vs conventional spirometry
Performance
As reported in the abstract
Mean resonant frequency (Fres)
ILD-positive
22.95
mean · SD 5.47
ILD-negative
15.01
mean · SD 6.01
ILD-positive vs ILD-negative: P = 0.001 · Extensive ILD vs Limited ILD: P = 0.001 · Extensive ILD vs ILD-negative: P = 0.011
Further findings
- Diagnostic accuracy of Fres (ROC) for extensive ILD
- 0.841 · AUC · cut-off 22.35 · sensitivity 73.1% · specificity 85%
- Diagnostic accuracy of Fres (ROC) for limited ILD
- 0.752 · AUC · cut-off 17.42 · sensitivity 80% · specificity 64%
Diagnostic accuracy of Fres (ROC) for extensive ILD
- Fres outperformed forced vital capacity (FVC) (% predicted) and DLCO (% predicted)
Original publication
Assessment of interstitial lung disease in systemic sclerosis using oscillometric methods: a novel approach to respiratory assessment. Rheumatology (Oxford). Published 28 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →