Sjögren's disease & overlap diseases
Investigation of pyroptosis-related hub genes and the immune microenvironment in primary Sjögren's syndrome
Authors' conclusion
This study uncovered a significant interaction between pyroptosis and the immune microenvironment in pSS patients. Besides, we identified five pyroptosis-related hub genes that might play a role in the pathogenesis of pSS.
Study context
- Population
- Gene expression data (NCBI GEO) and labial minor salivary gland biopsies from Primary Sjögren's syndrome (pSS) patients and non-pSS controls
- Participants
- 8 vs 10
- Comparison
- pSS vs healthy volunteer samples
- pSSn = 8
- Healthy volunteersn = 10reference
- Outcome
- Pyroptosis-related genes and immune microenvironment in pSS
Methodological detailsbioinformatic analysis of GEO datasets, immunohistochemical and immunofluorescence validation
- Bioinformatic analysis of GEO datasets
- Immunohistochemical and immunofluorescence validation
Main finding
As reported in the abstract
Differentially expressed genes (DEGs) identified between pSS and healthy volunteer samples
1494
Pyroptosis-related hub genes recognised (AIM2, CASP1, CASP3, IL6, TNF)
5
Original publication
Investigation of pyroptosis-related hub genes and the immune microenvironment in primary Sjögren's syndrome. Clin Exp Rheumatol. Published 12 January 2024. doi:10.
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