Sjögren's disease & overlap diseases
Sex differences in patient-reported outcome measures and clinical parameters in patients with Sjögren’s disease
Authors' conclusion
In this cohort of SjD patients from daily clinical practice, female and male patients showed distinct patterns of experienced symptoms and disease manifestations. The overall impact of SjD on HR-QoL was similar.
Study context
- Population
- Consecutive patients with clinical diagnosis of Sjögren's disease (SjD) fulfilling 2016 ACR/EULAR classification criteria, from daily clinical practice
- Participants
- 405 patients
- Exposure
- Female vs male patients with SjD
- Femalen = 360
- Malen = 45reference
- Outcome
- Sex differences in PROMs (sicca symptoms, fatigue, pain, HR-QoL) and clinical parameters
Methodological detailsprospective RESULT cohort and retrospective DiagnoSS registry, consecutive patients, 2016 ACR/EULAR classification criteria
- Prospective RESULT cohort and retrospective DiagnoSS registry
- Consecutive patients
- 2016 ACR/EULAR classification criteria
Main finding
As reported in the abstract
- Age at symptom onset, median (Female vs Male), years
- 37 vs. 51
- Diagnostic delay (Female vs Male), years
- 5 vs. 3
- ESSPRI dryness, median (Female vs Male); females scored worse on sicca patient-reported outcome measures (PROMs)
- 7 vs. 5
- UWS<0.1ml/min (Female vs Male); females had lower salivary gland function (SWS, UWS)
- 69% vs. 44%
- Pulmonary activity (Female vs Male)
- 1.7% vs. 6.7%
- Peripheral nervous system activity (Female vs Male)
- 3.4% vs. 11.1%
- Health-related quality of life (HR-QoL) (SF-36, EQ-5D-5L) comparable; EQ-5D-5L index median (Female vs Male)
- 0.76 vs. 0.74
- PASS (Female vs Male), comparable
- 72% vs. 70%
Observational data: associations, not effects.
Original publication
Sex differences in patient-reported outcome measures and clinical parameters in patients with Sjögren’s disease. Semin Arthritis Rheum. Published 9 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →