Sjögren's disease & overlap diseases
Damage accrual in Sjögren's disease. Prevalence, risk factors and impact on quality of life: a systematic review
Authors' conclusion
Organ damage in SjD is common nd progressive, reflecting sustained immunologic activity and agingrelated vulnerability. Damage burden predicts poorer outcomes and diminished HRQoL.
Study context
- Population
- Patients with Sjögren's disease (SjD) fulfilling the 2002 AECG and/or 2016 ACR/EULAR classification criteria; longitudinal and cross-sectional studies, PubMed 2005–202523 studies
- Outcome
- Prevalence, risk and associated factors of organ damage (Sjögren's Syndrome Damage Index (SSDI), SSDDI or conceptual definitions; lymphoma domain excluded)
Methodological detailsPRISMA guidelines, predefined PICO frameworks
- PRISMA guidelines
- Predefined PICO frameworks
Pooled result
As reported in the abstract
Prevalence of organ damage
Glandular damage, % of patients
25-86%
Systemic damage, % of patients
9-73%
Further pooled results
Predictors of damage accrual
- Most consistent predictors: older age, longer disease duration, higher baseline ESSDAI, hypergammaglobulinaemia, hypocomplementaemia, and absence of HCQ therapy
Long-term outcomes
- Pulmonary and renal involvement associated with increased mortality and hospitalisation rates
Health-related quality of life (HRQoL)
- Cumulative Sjögren's Syndrome Disease Damage Index (SSDDI) scores correlated with reduced HRQoL
Original publication
Damage accrual in Sjögren's disease. Prevalence, risk factors and impact on quality of life: a systematic review. Clin Exp Rheumatol. Published 4 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →