Sjögren's disease & overlap diseases
Implications of thyroid-related autoantibodies in patients with Sjögren's syndrome without overt thyroid diseases
Authors' conclusion
Latent thyroid autoimmunity, particularly TRAb and anti-TPO, may be associated with clinical and laboratory manifestations of pSS, such as disease activity or fatigue, even without overt thyroid dysfunction.
Study context
- Population
- Korean patients with pSS without overt thyroid illnesses190 women
- Participants
- 196 patients
- Outcome
- Prevalence of anti-thyroid autoantibodies and thyroid dysfunction, and their association with clinical and laboratory features
Main finding
As reported in the abstract
Anti-TG positive
31
15.8%
Anti-TPO positive
28
14.3%
TRAb positive
28
14.3%
Subclinical hypothyroidism (S-Hypo)
23
11.7%
Observational data: associations, not effects.
Further findings
Associations of thyroid autoantibodies with thyroid function and pSS features
- Lymphopenia, most influential independent predictor for TRAb, OR
- 5.541
- Anti-TG had no correlations with thyroidal function or pSS-related features
- Anti-TPO significantly associated with thyroid stimulating hormone (TSH) levels or anti-centromere antibody
- TRAb-positive patients had significantly higher EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) and clinical ESSDAI scores
Bidirectional association between fatigue-dominant group and anti-TPO-positive S-Hypo (multivariate regression)
- Fatigue-dominant group, OR
- 3.482
- Anti-TPO-positive S-Hypo, OR
- 7.586
- Multivariate regression analyses
Original publication
Implications of thyroid-related autoantibodies in patients with Sjögren's syndrome without overt thyroid diseases. Clin Exp Rheumatol. Published 17 March 2024. doi:10.
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