Sjögren's disease & overlap diseases
B cell receptor repertoire analysis in primary Sjogren’s syndrome salivary glands identifies repertoire features associated with clinical activity
Authors' conclusion
Through BCR repertoire analysis of pSS patient salivary glands, we identify a number of novel repertoire characteristics that may serve as useful indicators of clinical disease and disease activity.
Study context
- Population
- Patients with Primary Sjogren's syndrome (pSS): a small cohort profiled by paired scRNAseq and scBCRseq, and a wider cohort previously profiled through RNAseq
- Comparison
- Gland-infiltrating vs circulating B cells in pSS; pSS salivary gland B cells vs controls
- Outcome
- BCR repertoire characteristics
Methodological detailspaired scRNAseq and scBCRseq, receptor reconstruction analyses of RNAseq data
- Paired scRNAseq and scBCRseq
- Receptor reconstruction analyses of RNAseq data
Main finding
As reported in the abstract
- Trajectory progression pattern generated for infiltrated memory B cells in pSS
- Significant differences in BCR repertoires between peripheral blood and labial gland B cells (relative expansion, isotype usage, BCR clustering)
- Significant decreases in IgA2 isotype usage among labial and parotid gland B cells of pSS patients vs controls
- Positive correlation between kappa/lambda light chain usage and clinical disease activity
Original publication
B cell receptor repertoire analysis in primary Sjogren’s syndrome salivary glands identifies repertoire features associated with clinical activity. Arthritis Res Ther. Published 7 March 2024. doi:10.
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