Sjögren's disease & overlap diseases
The role of M1/M2 macrophage polarization in primary Sjogren’s syndrome
Authors' conclusion
This study reveals the presence of an significant imbalance in M1/M2 macrophages in pSS patients.
Study context
- Population
- Patients with pSS and healthy controls; minor salivary gland samples from 10 of these patients and 10 non-pSS controls
- Participants
- 30 / 30 / 10
- Comparison
- pSS vs healthy controls; pSS vs non-pSS controls
- pSSn = 30
- Healthy controlsn = 30reference
- Non-pSS controlsn = 10reference
- Outcome
- Role of M1/M2 macrophage polarization in pSS pathogenesis (serum cytokines by ELISA, CD86+ M1 and CD206+ M2 macrophages in PBMCs by flow cytometry, macrophage infiltration of minor salivary glands by immunofluorescence)
Methodological detailscase-control
- Case-control
Main finding
As reported in the abstract
- Significant increase in M1 macrophages in peripheral blood in pSS
- Significant increase in serum M1-related pro-inflammatory cytokines (IL-6, IL-23 and TNF-α) in pSS
- M2 macrophages downregulated in peripheral blood of pSS
- Minor salivary glands of pSS: M1 macrophage expression increased, M2 decreased
- Significantly positive correlation between proportion of M1 macrophages in peripheral blood mononuclear cells (PBMCs) and serum IgG and RF
Original publication
The role of M1/M2 macrophage polarization in primary Sjogren’s syndrome. Arthritis Res Ther. Published 14 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →