Sjögren's disease & overlap diseases
Primary Sjögren’s syndrome independently promotes premature subclinical atherosclerosis
Main finding · Subclinical atherosclerosis after matchingResult — go to the resultOdds ratio 1.82 95% CI 1.14–2.95Authors' conclusion
Subclinical atherosclerosis occurs earlier and more severely in patients with pSS.
Study context
- Population
- Patients with pSS from a rheumatology outpatient clinic and age- and sex-matched controls; aged 59.4 years (50.6–65.0), 19.1% male
- Participants
- 299 patients
- Exposure
- pSS vs age- and sex-matched controls
- pSSn = 199
- Controlsn = 100reference
- Outcome
- Subclinical atherosclerosis: plaque extent and carotid intima-media thickness (cIMT) by Doppler US
Methodological detailsage- and sex-matched controls (2:1 ratio), propensity score matching, consecutive inclusion
- Age- and sex-matched controls (2:1 ratio)
- Propensity score matching
- Consecutive inclusion
Main finding
Subclinical atherosclerosis after matching
Odds ratio
1.82
95% CI 1.14–2.95
pSSvs Controls
OR 1.82 (95% CI 1.14–2.95)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| cIMT and plaque occurrence, pSS with vs without organ involvement (subgroup)OIvs No OIPlaque occurrence | 1.74 (1.02–3.01) | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | P value |
|---|---|
| cIMT and plaque occurrence, pSS with vs without organ involvement (subgroup)OI vs No OI | P = 0.025 |
OxLDL ab in pSS
- OxLDL ab tended to be lower in patients with plaque
- P = 0.052
- Higher Oxidized Low Density Lipoprotein (oxLDL) ab correlated with ESSDAI
- P < 0.001
- Higher oxLDL ab correlated with SSA/Ro antibodies
- P = 0.026
Original publication
Primary Sjögren’s syndrome independently promotes premature subclinical atherosclerosis. RMD Open. Published 24 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →