Sjögren's disease & overlap diseases
Distinctive profile of monomeric and polymeric anti-SSA/Ro52 immunoglobulin A1 isoforms in saliva of patients with primary Sjögren’s syndrome and Sicca
Authors' conclusion
Salivary anti-Ro52 polymeric IgA1 isoform is associated with glandular inflammation in pSS, while salivary monomeric IgA1 is associated with Sicca.
Study context
- Population
- Patients with Primary Sjögren's syndrome (pSS), patients with Sicca and healthy controls; salivary anti-SSA/Ro52 antibodies
- Participants
- 34 / 35 / 41
- Exposure
- pSS vs non-pSS Sicca vs healthy controls
- pSSn = 34
- Siccan = 35
- Healthy controlsn = 41reference
- Outcome
- Salivary IgG/M/A, IgG, IgA, IgA isotypes (IgA1, IgA2) and IgA1 subclasses (polymeric, monomeric) to anti-SSA/Ro52
Methodological detailsnovel electrochemical detection platform (Electric Field-Induced Release and Measurement)
- Novel electrochemical detection platform (Electric Field-Induced Release and Measurement)
Main finding
As reported in the abstract
Salivary anti-SSA/Ro52 antibodies
- Saliva IgG/M/A, IgG, IgA, IgA isotypes and IgA1 subclasses to anti-SSA/Ro52 differed significantly between pSS, non-pSS Sicca and healthy subjects
- Elevated monomeric IgA1 in non-pSS Sicca
- Elevated polymeric IgA1 in pSS
Observational data: associations, not effects.
Further findings
Correlation of salivary polymeric IgA1 with focus score
- Polymeric IgA1 vs focus score, r2
- 0.467
- Polymeric IgA1 vs focus score, p
- P = 0.001
- Monomeric IgA1 did not correlate with focus score
Original publication
Distinctive profile of monomeric and polymeric anti-SSA/Ro52 immunoglobulin A1 isoforms in saliva of patients with primary Sjögren’s syndrome and Sicca. RMD Open. Published 10 April 2024. doi:10.
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