Sjögren's disease & overlap diseases
Immunoglobulin G and immunoglobulin A anti-Ro52 in plasma and saliva show little association with disease activity in patients with primary Sjögren’s disease
Authors' conclusion
IgA and IgG anti-Ro52 autoantibodies in saliva and plasma showed an inverse correlation with disease activity but significant positive association with immune activity in patients with SjD.
Study context
- Population
- Norwegian cross-sectional cohort of patients with Primary Sjögren's disease (pSjD)
- Participants
- 113 participants
- Outcome
- Frequency of IgG and IgA anti-Ro52 autoantibodies in plasma and saliva, and associations between disease activity and autoantibody titres
Methodological detailsindirect in-house enzyme-linked immunosorbent assay (ELISA)
- Indirect in-house ELISA
Main finding
As reported in the abstract
Plasma immunoglobulin G (IgG) anti-Ro52 positive
73%
Plasma IgA anti-Ro52 positive
47%
Saliva IgA anti-Ro52 positive
34%
Saliva IgG anti-Ro52 positive
17%
Observational data: associations, not effects.
Further findings
Pain (ESSPRI) by plasma IgG anti-Ro52 titre; low titre had higher probability of reporting pain
- RR
- 0.48 (95% CI 0.29-0.80, p = 0.002)
Plasma IgA anti-Ro52 and focus score
- Correlated significantly with the focus score
Original publication
Immunoglobulin G and immunoglobulin A anti-Ro52 in plasma and saliva show little association with disease activity in patients with primary Sjögren’s disease. Scand J Rheumatol. Published 6 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →