Sjögren's disease & overlap diseases
Increased Interferon Signaling in Vaginal Tissue of Patients With Primary Sjögren Syndrome
Authors' conclusion
Upregulation of IFN signaling in vaginal tissue of women with pSS, along with its association with tissue pathology, suggests that IFNs contribute to inflammation of the vaginal wall and potentially also to clinical symptomatology (ie, vaginal dryness).
Study context
- Population
- Vaginal biopsies of premenopausal women with primary Sjögren syndrome (pSS) experiencing vaginal dryness and age-matched non-pSS controls
- Participants
- 8 vs 7
- Comparison
- Premenopausal patients with pSS with vaginal dryness vs age-matched non-pSS controls
- pSSn = 8
- Non-pSS controlsn = 7reference
- Outcome
- Inflammatory pathway activity in vaginal tissue
Methodological detailsage-matched controls, NanoString gene expression, TaqMan Real-Time PCR validation, immunohistochemistry
- Age-matched controls
- NanoString gene expression
- TaqMan Real-Time PCR validation
- Immunohistochemistry
Main finding
As reported in the abstract
Pathway scores in vaginal biopsies, pSS vs non-pSS controls
- Differences in interferon (IFN) signaling confirmed by PCR and MxA tissue staining
- No CD123+ pDCs detected in vaginal biopsies
- IFN-stimulated gene expression correlated positively with CD45+ cell numbers in vaginal biopsies and serum anti-SSA/Ro positivity
- pSS vs Non-pSS controls: P < 0.01
- pSS vs Non-pSS controls: P < 0.01 for both pathways
- pSS vs Non-pSS controls: P = 0.02
- pSS vs Non-pSS controls: P = 0.04
Original publication
Increased Interferon Signaling in Vaginal Tissue of Patients With Primary Sjögren Syndrome. J Rheumatol. Published 1 April 2024. doi:10.
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