Sjögren's disease & overlap diseases
Possible role for IL-40 and IL-40-producing cells in the lymphocytic infiltrated salivary glands of patients with primary Sjögren’s syndrome
Authors' conclusion
Our results suggest that IL-40 may play a role in pSS pathogenesis and pSS-associated lymphomas.
Study context
- Population
- Patients with primary Sjögren syndrome (pSS) and controls; Minor salivary gland (MSG) biopsies, and parotid gland biopsies from pSS-associated lymphoma
- Participants
- 29 vs 24
- Comparison
- pSS vs controls
- pSSn = 29
- Controlsn = 24reference
- Outcome
- IL-40 expression in pSS and pSS-associated lymphomas
Methodological detailscase-control
- Case-control
Main finding
As reported in the abstract
- IL-40 significantly increased in lymphocytic infiltrated MSG of pSS; correlated with focus score and with IL-4 and TGF-β expression
- Serum IL-40 increased in pSS; levels correlated with ESSDAI score
- B cells the major source of IL-40 at tissue and peripheral level
- Peripheral blood mononuclear cells (PBMCs) from pSS exposed to rIL-40 in vitro released IFN-γ (B cells, T-CD8+) and TNF-α and IL-17 (T-CD4+ and T-CD8+)
- IL-40 expression increased in parotid glands of pSS-associated lymphomas
- IL-40-driven NETosis evidenced in neutrophils from pSS
Original publication
Possible role for IL-40 and IL-40-producing cells in the lymphocytic infiltrated salivary glands of patients with primary Sjögren’s syndrome. RMD Open. Published 3 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →