Sjögren's disease & overlap diseases
Association of Circulating Antibody‐Secreting Cell Maturity With Disease Features in Primary Sjögren's Syndrome
Authors' conclusion
Quantity and maturity of ASCs in primary SS patients are increased and correlate with disease parameters. A higher maturity index of ASCs marks a pro-survival and proinflammatory phenotype.
Study context
- Population
- Primary Sjögren's syndrome (SS) patients and healthy controls; circulating antibody-secreting cells (ASCs) (CD3-CD14-CD27+CD38++)
- Participants
- 21 vs 10
- Exposure
- pSS patients vs healthy controls
- pSSn = 21
- Healthy controlsn = 10reference
- Outcome
- Circulating ASCs in peripheral blood
Methodological detailsspectral flow cytometry, t-distributed stochastic neighbor embedding
- Spectral flow cytometry
- T-distributed stochastic neighbor embedding
Main finding
As reported in the abstract
P = 0.048
Observational data: associations, not effects.
Further findings
CD19- ASCs (mature phenotype)
P = 0.005
Correlations of ASC phenotype
- CXCR3+ phenotype vs ASC maturity index, r (P = 0.007)
- 0.568
- CXCR3+ phenotype vs IL-10 expression, r (P < 0.001)
- −0.769
- Maturity index vs myeloid cell leukemia 1, r (P = 0.007)
- 0.567
ASC frequency and/or maturity vs disease parameters
- Correlated with ANA and anti-La/SSB titers, salivary gland focus scores and ocular staining scores
Original publication
Association of Circulating Antibody‐Secreting Cell Maturity With Disease Features in Primary Sjögren's Syndrome. Arthritis Rheumatol. Published 22 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →