Sjögren's disease & overlap diseases
The role of imbalanced CD226/TIGIT on activated peripheral double-negative T cells in the pathogenesis of primary Sjögren's syndrome
Authors' conclusion
The balance between CD226 and TIGIT on DN T cells was disturbed and correlated with the disease activity in pSS patients, which may be implicated in the pathogenesis of pSS.
Study context
- Population
- Patients with pSS; peripheral blood DN (CD3+CD56-TCRαβ+CD4-CD8-) T cells
- Outcome
- Peripheral DN T cells in pSS: frequency, CD226/TIGIT balance and correlations
Methodological detailsflow cytometry, in vitro stimulation
- Flow cytometry
- In vitro stimulation
Main finding
As reported in the abstract
- Percentage of DN T cells in peripheral blood of pSS patients (expanded), mean±SD
- 1.77±0.66%
- Correlation of DN T cells with IgG
- r=0.451, p<0.05
- Correlation of DN T cells with C3
- r=−0.438, p<0.05
- Correlation of DN T cells with C4
- r=−0.470, p<0.05
- TIGIT/CD226 expression ratio on DN T cells elevated in pSS and correlated with ESSDAI scores≥5
- r=0.743, p<0.05
Original publication
The role of imbalanced CD226/TIGIT on activated peripheral double-negative T cells in the pathogenesis of primary Sjögren's syndrome. Clin Exp Rheumatol. Published 5 October 2023. doi:10.
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