Sjögren's disease & overlap diseases
Anti-SMN autoantibodies in mixed connective tissue disease are associated with a severe systemic sclerosis phenotype
Authors' conclusion
Their presence, especially at high-titres, was associated with a severe systemic sclerosis (scleroderma) phenotype including myositis, myocarditis and lower GI involvement.
Study context
- Population
- Anti-U1RNP+ mixed connective tissue disease (MCTD) patients; median age at MCTD diagnosis 40.6 years, follow-up 12 yearsretrospective MCTD cohort
- Participants
- 66 patients
- Exposure
- Anti-SMN+ vs anti-SMN- anti-U1RNP+ MCTD patients
- Anti-SMN+n = 39
- Outcome
- Phenotypic (clinical) features of MCTD with vs without anti-SMN aAbs
Methodological detailstwo-tailed Fisher's exact test, logistic regression
- Two-tailed Fisher's exact test
- Logistic regression
Main finding
As reported in the abstract
Clinical features, anti-SMN+ vs anti-SMN-
Fingertip pitting scars: anti-SMN+ 23% vs anti-SMN- 4%, p=0.04
23% vs 4%
Observational data: associations, not effects.
Further findings
| Outcome | Anti-SMN+ |
|---|---|
| Prevalence of anti-SMN aAbsBased on the highest available titre | 59% |
| Low titre | 10 (26%) |
| High titre | 29 (74%) |
Original publication
Anti-SMN autoantibodies in mixed connective tissue disease are associated with a severe systemic sclerosis phenotype. RMD Open. Published 4 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →