Sjögren's disease & overlap diseases
Predictors for future development of systemic lupus erythematosus in Korean Sjögren’s syndrome patients
Authors' conclusion
Shorter disease duration and higher disease activity of SS at baseline may be risk factors for future SLE development. Serologic predictors of SLE development are hypocomplementemia, leukopenia, thrombocytopenia, and positivity for anti-dsDNA, anti-RNP, and anti-ribosomal P antibodies.
Study context
- Population
- Sjögren's syndrome (SS) patients without other autoimmune diseases at baseline who visited the hospital between January 2012 and March 2021, Koreamedian follow-up 1083.5 days
- Participants
- 1,082 patients
- Exposure
- SS patients who developed SLE vs those who did not
- SS/SLEn = 49
- Outcome
- Future SLE development (2012 SLICC or 2019 EULAR/ACR classification criteria) and its baseline predictors
Methodological detailssingle-centre, Kaplan-Meier method, Cox proportional hazards models
- Single-centre
- Kaplan-Meier method
- Cox proportional hazards models
Main finding
As reported in the abstract
- Shorter SS disease duration (<3 years)
- HR 2.12; P = 0.0328
- High ESSDAI
- HR 8.24; P < 0.0001
- Leukopenia
- HR 4.17; P = 0.0005
- Thrombocytopenia
- HR 3.38; P = 0.0059
- Hypocomplementemia
- HR 29.06; P < 0.0001
- Anti-dsDNA positive
- HR 13.70; P < 0.0001
- Anti-RNP positive
- HR 3.82; P = 0.0027
- Anti-ribosomal P positive
- HR 6.70; P = 0.0002
- Developed SLE
- 49 (4.5%)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Baseline ESSDAI scoreSignificantly higher in SS/SLE | P < 0.001 |
| Lymphadenopathy · baselineMore in SS/SLE | P = 0.015 |
| Renal involvement · baselineMore in SS/SLE | P = 0.017 |
Original publication
Predictors for future development of systemic lupus erythematosus in Korean Sjögren’s syndrome patients. Lupus. Published 26 September 2023. doi:10.
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