Sjögren's disease & overlap diseases
Risk of cognitive disorders in patients with primary Sjögren’s disease: data from Korean Health Insurance Service
Main finding · Total cognitive disordersResult — go to the resultAdjusted hazard ratio 1.48 95% CI 1.36–1.63Authors' conclusion
pSjD was associated with increased risks of multiple cognitive disorders.
Study context
- Population
- Patients newly diagnosed with pSjD, 2010–2021, and matched controls; Korean National Health Insurance Service datamatched cohort
- Participants
- 12,731 vs 36,514
- Exposure
- pSjD vs propensity score-matched controls
- pSjDn = 12,731
- Controlsn = 36,514reference
- Outcome
- Composite of:
- Alzheimer's dementia
- Vascular dementia
- Secondary dementia
- Unclassified dementia
- Mild cognitive impairment (total cognitive disorders)
Methodological detailsnationwide, propensity score-matched, multivariable Cox regression, age-stratified analyses
- Nationwide
- Propensity score-matched
- Multivariable Cox regression
- Age-stratified analyses
Main finding
Total cognitive disorders
Adjusted hazard ratio
1.48
95% CI 1.36–1.63
pSjDvs Controls
aHR 1.48 (95% CI 1.36–1.63)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Alzheimer's dementia | 1.48 (1.35–1.63) | |
| Secondary dementia | 2.24 (1.45–3.48) | |
| Unclassified dementia | 1.43 (1.21–1.70) | |
| Mild cognitive impairment | 1.62 (1.41–1.85) | |
| Mild cognitive impairment, age <65 years (subgroup) | 1.46 (1.06–2.01) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Age 65-74 years (subgroup): total cognitive disorders, Alzheimer's dementia (AD) and mild cognitive impairment (MCI)
- pSjD associated with increased risks of total cognitive disorders, AD and MCI
Original publication
Risk of cognitive disorders in patients with primary Sjögren’s disease: data from Korean Health Insurance Service. RMD Open. Published 24 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →