Sjögren's disease & overlap diseases
Risk of gastrointestinal cancers in patients with primary Sjögren’s syndrome in Korea: a nationwide retrospective cohort study
Main finding · All gastrointestinal cancersResult — go to the resultAdjusted hazard ratio 1.240 95% CI 0.990–1.543Authors' conclusion
pSS was associated with increased risks of colorectal and pancreatic cancers, particularly among females and older adults.
Study context
- Population
- Participants of the National Health Insurance Service-National Sample Cohort (NHIS-NSC) database, Korea, followed up until 2019NHIS-NSC database
- Participants
- 320,082 participants
- Exposure
- pSS vs non-pSS general population
- pSSn = 850
- non-pSSn = 319,232reference
- Outcome
- All gastrointestinal cancers
Methodological detailsnationwide, multivariable Cox proportional hazards models
- Nationwide
- Multivariable Cox proportional hazards models
Main finding
As reported in the abstract
Adjusted hazard ratio
1.240
95% CI 0.990–1.543
pSSvs non-pSS
aHR 1.240 (95% CI 0.990–1.543)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Colorectal cancer (site-specific) | 1.597 (1.122–2.273) | |
| Pancreatic cancer (site-specific) | 2.294 (1.267–4.151) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Subgroup analyses (sex, age)
- Association more prominent in females and elderly (aged ≥ 60) individuals
Original publication
Risk of gastrointestinal cancers in patients with primary Sjögren’s syndrome in Korea: a nationwide retrospective cohort study. Arthritis Res Ther. Published 25 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →